Fierce Pharma ranks the top 10 drug launch disasters in the past five years

A recent L.E.K. Consulting report found that about 40% of meds approved between 2004 and 2016 underperformed Wall Street’s prelaunch sales forecasts by over 20% in their first three years on market.

To follow is a list of 10 drug launches from the past five years that suffered some of the most significant failures. The companies range from big pharma to biotech startups in various therapeutic areas.

Merck details Keytruda's Herceptin combo stomach cancer win

The FDA has granted Merck the go-ahead based on initial data from its first 264 patients that are enrolled in a study that combines Keytruda with Roche’s Herceptin and chemotherapy. This treatment had tumors shrink in 74.4% of patients with newly diagnosed, HER2-positive gastric or gastroesophageal junction cancer. That is considerably more than the 51.9% for the standard-of-care Herceptin-chemo treatment.