Researchers at the University of Pennsylvania have found a new method for attacking MYC, a cancer-causing gene that has proven difficult to target with drugs.
They have found that by blocking the protein, called ATF4, causes cancer cells to make too much of another type of protein family called 4E-BP. That causes the cancer cells so much stress that they die.
The researchers believe that the discovery, published in the journal Nature Cell Biology, could spark new ideas for cancer therapeutics, because experimental compounds that block the synthesis of ATF4 have already been developed.
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